Researchers at Mount Sinai Health System have found that generative AI such as GPT-4 can help predict whether an emergency room patient needs to be admitted to the hospital even with only minimal training on a limited number of records.

Investigators at the Icahn School of Medicine at Mount Sinai published details of the research in the May 21 online issue of the Journal of the American Medical Informatics Association.

In their retrospective study, the researchers analyzed records from seven Mount Sinai Health System hospitals, using both structured data, such as vital signs, and unstructured data, such as nurse triage notes, from more than 864,000 emergency room visits while excluding identifiable patient data. Of these visits, 159,857 (18.5 percent) led to the patient being admitted to the hospital. 

The researchers compared GPT-4 against traditional machine-learning models such as Bio-Clinical-BERT for text and XGBoost for structured data in various scenarios, assessing its performance to predict hospital admissions independently and in combination with the traditional methods.

“We were motivated by the need to test whether generative AI, specifically large language models (LLMs) like GPT-4, could improve our ability to predict admissions in high-volume settings such as the Emergency Department,” said co-senior author Eyal Klang, M.D., director of the Generative AI Research Program in the Division of Data-Driven and Digital Medicine (D3M) at Icahn Mount Sinai, in a statement. “Our goal is to enhance clinical decision-making through this technology. We were surprised by how well GPT-4 adapted to the ER setting and provided reasoning for its decisions. This capability of explaining its rationale sets it apart from traditional models and opens up new avenues for AI in medical decision-making.”

While traditional machine-learning models use millions of records for training, LLMs can effectively learn from just a few examples, the researchers said. They added that LLMs can incorporate traditional machine-learning predictions, improving performance.

“Our research suggests that AI could soon support doctors in emergency rooms by making quick, informed decisions about patient admissions. This work opens the door for further innovation in health care AI, encouraging the development of models that can reason and learn from limited data, like human experts do,” said co-senior author Girish N. Nadkarni, M.D., M.P.H., in a statement.  “However, while the results are encouraging, the technology is still in a supportive role, enhancing the decision-making process by providing additional insights, not taking over the human component of healthcare, which remains critical,” added Nadkarni, who is the Irene and Dr. Arthur M. Fishberg Professor of Medicine at Icahn Mount Sinai, Director of The Charles Bronfman Institute of Personalized Medicine, and System Chief of D3M.

The research team is investigating how to apply large language models to healthcare systems, with the goal of harmoniously integrating them with traditional machine-learning methods to address complex challenges and decision-making in real-time clinical settings.

“Our study informs how LLMs can be integrated into healthcare operations. The ability to rapidly train LLMs highlights their potential to provide valuable insights even in complex environments like healthcare,” added Brendan Carr, M.D., M.A., M.S., a study co-author and emergency room physician who is CEO of Mount Sinai Health System. “Our study sets the stage for further research on AI integration in health care across the many domains of diagnostic, treatment, operational, and administrative tasks that require continuous optimization.”



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