How DMSO Safely Eliminates 'Incurable' Pain

• Conduction blocking — Many different nerves exist in the body. One group, known as the “small fibers” are responsible for transmitting specific sensations and they (particularly the C fibers) are frequently linked to debilitating chronic pain syndromes (e.g., small fiber neuropathy — characterized by sensations of pins-and-needles, pricks, tingling, and numbness alongside burning pain and electrical shocks).

Note: The five most common symptoms of COVID vaccine injuries, in order, are fatigue, post-exertional malaise, brain fog, small fiber neuropathy, and dysautonomia.

DMSO selectively blocks the conduction of the small fibers, thereby stopping the pain without causing significant damage to the rest of the body or having a tolerance develop to it (rather DMSO typically becomes more effective with time). To illustrate:

• Choline esterase inhibition — Acetylcholinesterase inhibitors increase acetylcholine (the neurotransmitter of the parasympathetic nervous system) by blocking their degradation. Numerous studies show DMSO is an effective acetylcholine esterase inhibitor,^{20,21,22,23,24,25,26} and that it blocks the inhibitory effects of the sympathetic nervous system.²⁷

Chronic pain has been linked to excessive sympathetic activity, and counterbalancing that with an acetylcholinesterase inhibitor has shown promise for treating chronic pain.²⁸ However, unlike those drugs, DMSO does not have a risk of creating excessive acetylcholine levels (possibly because at higher doses it instead blocks cholinergic transmission,²⁹ or because it is a competitive rather than irreversible inhibitor³⁰).

• Anti-inflammatory — Many of my colleagues who used DMSO in practice find it to be one of the most effective anti-inflammatory agents out there. DMSO in turn, has been repeatedly shown to:^31,32

Research also shows DMSO prevents experimentally induced edema,^33,34,35 (including severe forms³⁶), allergic eczema,³⁷ contact dermatitis,^38,39 tissue necrosis,^40,41 granuloma formation,⁴² arthritis,^43,44,45 and joint stiffness following injury.⁴⁶

Since inflammation is a key cause of pain (e.g., “chronic inflammatory pain” is well recognized⁴⁷), this likely accounts for some of DMSO’s analgesic properties.

• Muscle relaxation — DMSO tends to relax skeletal muscle⁴⁸ while simultaneously enhancing the contraction of other muscles⁴⁹ (e.g., 3% to 6% DMSO enhances the contraction of the heart and stomach).

DMSO applied topically to the skin of patients produces electromyographic evidence of muscle relaxation 1 hour after application,⁵⁰ while another study found 50% DMSO prevented the contraction of frog skeletal muscles.⁵¹

A 1966 study found that (as shown by electromyography) muscles in spasm will relax within 60 minutes of topical application. It also found that this relaxation could be used to treat headaches associated with cervical disease and complex regional pain syndrome.⁵²

As muscle tension is a frequent cause of pain and musculoskeletal disorders, this property likely accounts for some of its efficacy for those conditions.

• Circulatory enhancement — DMSO removes blood clots and increases blood circulation⁵³ and has been recognized to eliminate the pain associated with blood clots. This aligns with Chinese medicine’s view that poor blood flow causes sharp, piercing pain.⁵⁴

Note: One of the most common side effects of vaccinations is them creating tiny blood clots (discussed further here), which then trigger microstrokes throughout the body that can often be detected with an appropriate neurological examination. To this point, many of the injuries reported from the original smallpox vaccine matched the same unusual pains and neurological symptoms associated with blood stasis in Chinese Medicine.

• A 1983 study⁵⁵ using a common research metric (how mice respond to heat and tail flicks) found that DMSO produced an analgesic effect comparable in strength to morphine.

However, this effect was assessed to be due to a different mechanism as an opioid receptor blocker (naloxone) did not affect DMSO’s ability to eliminate pain, DMSO did not produce any of the side effects seen with opioids, and DMSO’s effect lasted far longer (4 to 6 hours and in some cases over 24 hours — whereas in contrast morphine typically lasted less than 2 hours).

Note: Another mouse study using similar tests also found that DMSO blocks pain.⁵⁶

• It treats a very wide range of pain conditions, including ones other analgesics can’t address. For example, case reports exist of DMSO treating phantom pain⁵⁷ (pain outside the body where an amputated limb had previously existed).

• Rather than the body developing a resistance to it (which is what commonly happens with opioids), DMSO often becomes more effective at eliminating pain with subsequent doses, and in many cases, is needed less and less frequently (or not at all because the condition is resolved).

Because of this, while acute pain rapidly responds to DMSO, chronic pain conditions often take 4 to 7 days of applications for DMSO to begin taking effect and 6 to 8 weeks for lasting relief to occur (e.g., to quote one patient, “after twenty-four DMSO injections, I was completely pain-free”).

• In many cases, as is seen with other applications of DMSO, due to DMSO rapidly spreading throughout the body, the effect is systemic. For example, one study found 65% of patients experienced pain relief if DMSO was applied at the site of pain,⁵⁸ whereas 61.5% experienced comparable relief when DMSO was applied somewhere further away in the body. Because of this, DMSO has been found to help a wide range of pain conditions.

• Stanley Jacob MD reported on 59 patients with headaches from a variety of causes, of whom over 75% responded to DMSO.

This included 13 out of 17 patient with years of chronic neck pain from cervical arthritis that triggered headaches, (who then required a gradually decreasing DMSO dose), 4 out of 5 patients with sinus headaches improved from DMSO, 2 out of 2 patients with temporal arteritis (causing severe head pain) who fully recovered after DMSO and 26 out of 35 patients who’d had trigeminal neuralgia for more than a year with numerous failed treatments (13 of whom then had a full recovery).⁶⁰

• Another study found DMSO both relaxes the cervical musculature and alleviates tension headaches.⁶¹

• A study included two older patients with cancer pain DMSO, one of whom had an excellent response to treatment and one who had a good response.⁷⁴

• Another study found that of 7 patients with metastatic cancer pain, DMSO gave 2 a full remission and 2 a partial remission.⁷⁵

• One of the most well known examples was Otis Bowen MD (a popular second term Indiana governor) who “illegally” used topical DMSO to treat his wife’s pain from terminal multiple myeloma and then publicly denounced the FDA’s absurd embargo on it at the AMA’s 1981 national meeting.⁷⁶

Remarkably, a few years later, Bowen became Reagan’s Secretary of Health and Human Services, but even then, with this highly ethical doctor at the helm of the HSS, DMSO was unable to overcome the FDA’s prohibition of it.⁷⁷

• A rat study found administering DMSO into a wound before closing it significantly reduced the subsequent pain and guarding the rats had, suggesting this approach could address a common complication of surgery.⁷⁹

• A 1967 study found that DMSO applied to the incision sites of thoracotomy (open chest surgery) patients in concentrations of 60% to 80% resulted in significant pain relief, and reduction of the opioids needed (which in turn led to fewer gastrointestinal complications).

These patients as a group were able to cough more effectively, move more easily both in and out of bed, resume early motion of the arm and shoulder, and in general enjoy a more rapid and less complicated postoperative course.⁸⁰

• Another study gave 90% DMSO to 64 postpartum women with episiotomy pain and found that over half had pain relief and a reduction in swelling and that there was a significant improvement in mobility (with some patients who had left the hospital then requesting to resume DMSO to alleviate subsequent pain).⁸¹